Ender Lillies: Quietus of the Knights is a platform game based in a fictional world called Land's End. Rainfall has transformed all living things into monsters known as the Blighted. You control Lily, a bright white figure, who awakens as the last survivor. The game is unusual because Lily never attacks enemies; instead she uses fallen foes to attack for her.

You explore a dark forest, underground caverns and a grand castle, fighting off enemies who turn to stone once defeated. You can then release them from their curse and recruit them as an ally, giving access to their attacks, weapons and powers.

Each weapon has limited life or number of uses, adding another layer of strategy to the combat. Boss battles are fast paced as you attempt to evade and dash away from harmful attacks, as well as using melee, ranged, magic, and other attacks.

The game is visually pleasing with a unique art style of layered backgrounds and detailed scenery adding depth to the 2D game. Along with complex combat movements that open up to a large range of combos to have the advantage in a close battle.